Relationship Between The Principle Of Utility And Moral Rules

Evaluate Mill’s understanding of the relationship between the principle of utility and moral rules. In this essay I will argue that Mill thinks that there is a strong relationship between the two concepts, although he regards moral rules as having a subordinate relationship towards the principle of utility. Mill is a rule utilitarian who believes moral rules are useful guidelines for everyday uses, but reverts to the principle of utility in complex moral situations. In this essay I will also argue for the advantages of Mill’s understanding of the relationship between the two concepts as it incorporates religious moral rules, helps prevent ‘evil’ acts, and creates an ethical theory suitable and practical for daily use. Mill’s predecessor, Jeremy Bentham is an act utilitarian who looks at the consequences of each individual act and calculates utility each time the act is performed. In contrast, Mill is a rule utilitarian who introduces the idea of secondary principles which we should adopt in order to guide our actions and which support the primary ‘greatest happiness’ principle. These rules are adopted because experience has shown that adherence to these rules tends to produce the greatest happiness as he looks at the consequences of having everyone follow a particular rule and calculates the overall utility of accepting or rejecting the rule. However, you can break the rule if certain consequences require it as the aim for the greater good is the most important. You mayShow MoreRelatedThe Similarities and Differences Between Different Ethical Theories651 Words   |  3 PagesSimilarities and Differences in Ethics: The main aim of any ethical theory is to do what is right and good since it involves moral rules or acting based on specific ethical values. In certain cases, the right and good as well as the ethical rules and values are sometimes common to various ethical theories. Even though ethical theories have different reasons for application, there is an overlap in these theories that result in similar conduct in an ethical situation. There are various ethical theoriesRead MoreSimilarity Between Religion And Utilitarianism813 Words   |  4 Pagessimilarities between religion and utilitarian, religion is not utilitarian. The basic idea of utilitarianism is hat actions are judged according to their consequences and the relevant consequence of every action is happiness. There is a similarity between religion and utilitarianism. For example, love includes wanting happiness and religious principles such as loving others the way you love yourself and doing to others what you expect them to you are founded on utilitarian principles. The ultimateRead MoreBroad-Based Blac Economic Empowerment996 Words   |  4 Pagesconsequences of BBBEE and other affirmative action tools implemented by the South African Government, and the role of these measures in the present and future workplace. Stakeholder Theory Stakeholder theory states that managers within a company have a moral duty beyond merely maximizing profits and not involving potential role players (Beauchamp 2009). It says that a manager has ethical obligations to help all stakeholders within a company as well as external stakeholders. These stakeholders includeRead MoreAnalyzing the Parable of the Sadhu1559 Words   |  7 PagesHence it becomes ambiguous to justify his actions. Kantian Ethics: Should abide by the following 2 principles: *Maxim should become a universal law *Never treat people simply as means to an end but always at the same time as ends in themselves In the parable, Stephen says that the hikers would have treated the Sadhu differently if he had been from the same ethnic group as them. However Kantian principle forbids such behaviour. One should treat all equally irrespective of ethnicity, caste, sex etcRead MoreThe Connection Between Law And Morality1718 Words   |  7 Pagespopular conception of the connection between law and morality is that in some way the law exists to promote morality, to preserve those conditions which make the moral life possible, and thus to enable men to lead sober and industrious lives. Morality is a value-impregnated concept relating to certain normative patterns which aim at the augmentation of good and reduction of evil on individual and social life. The sphere of morality denotes rules or principles governing human behaviour which applyRead MoreThe Ethical Theory Of Ethics898 Words   |  4 Pages Ethics also known as moral philosophy is a branch of philosophy that involves the classification, defense and endorsement of concepts of right and wrong actions that govern an individual’s behavior. Based on the â€Å"Billy and Suzy† scenario from a utilitarian ethical perspective, I would choose to follow Billy to ensure that nothing transpires between him and the lady he left the bar with. The best action to take would be to follow him and ensure that he does not leave for the night with the lady.Read MoreThree Approaches to Making Ethical Decisions Within an Educational Institution1700 Words   |  7 Pageseducational institutions. Philosophical, s ocial and moral principles and values accentuate ethical decision-making and shape the foundation for understanding the relationship between an individuals values and decisions made in educational institutions. Administrating what an individual knows is right is not always straightforward, and determining what is right is often difficult (Beckner, 2004). An exact collection of ethical principles and moral concepts in decision-making does not exist. An understandingRead MoreFeminist Thought and Ethics of Care Essay993 Words   |  4 Pagescare, an equally valid moral perspective, is usually disregarded because of male bias. The two perspectives are often pleasant-sounding, but a need for care point of view precedence exists. While truth is evident in both these statements, the problem of distinguishing between them becomes apparent soon after. Many feminist look to psychologist Carol Gilligans research for evidence to confirm the difference between characteristically male and female approaches to moral decision making. Her researchRead MoreCustomer Perception on Buying House5873 Words   |  24 PagesPrinciples of Ethical Reasoning Adapted from Business Ethics, Concepts and Cases: Manuel Velasquez (2006) Prentice Hall Utilitarianism Utilitarianism is a general term for any view that holds that actions and policies should be evaluated on the basis of the benefits and costs they will impose on society. In any situation, the â€Å"right† action or policy is the one that will produce the greatest net benefits or the lowest net costs (when all alternatives have only net costs). Many businessesRead MoreEthical Theories And Principles Of Medical Ethics Essay2030 Words   |  9 PagesMedical Ethics PHIL 148 @ Binghamton University, Sum 11 By Brandon Ethical Theories and Principles This week we covered the various ethical theories and principles we will be using throughout the course. Test your knowledge of the readings using the quiz. Instructions Each week a quiz will be provided on the second Reading Day (Tuesday. Don t let this practice quiz on a Friday throw you off!). You can use this quiz to test your textual knowledge and reading abilities and to guarantee a firm foundation

Information for Personal Auto Policy Analysis Example

Essays on Information for Personal Auto Policy Analysis Essay Unit Information for Personal Auto Policy Analysis Type of Car Location Principle place of Garaging Primary usage of car Mercedes Benz A brand new Mercedes Benz 2010 model Located in New York City Owner Maintains the car through a personal mechanic Primarily for pleasure Bus A 2005 model school bus Ohio State Garaging is done through a qualified school garage This car is used mainly for school trips and picking students to and from school. Apart from Building and Employer’s insurance, Motor insurance is also one of the small statutory insurance. Under the Road traffic Act, it is against the law to take your car to the road without proper and up to date car insurance. Any travel involves risk. There is always the lurking peril that imminent damage may occur to your car, to third parties as well as to yourself. Consequently, motorist should be prudent when choosing the type of insurance cover that they go for. Moreover, it is possible to save some money whilst still getting a decent insurance cover (Boylan and Mark 2009). Every Insurance cover has its unique benefits that come with its adoption as well as the considerations that one should consider before taking a certain insurance cover. Depending on the type of vehicle and the insurer’s budget, insurance companies have made available various auto insurance policies for policy holders to choose from. Liability insurance covers a policy holder in the event an accident occurs and the insured is deemed to be the cause of the accident. This means that the policy holder’s actions are the cause of the event that causes the accident. This policy covers and redeems the costs incurred in repairing of the damaged property. Dun Bradstreet Insurance Company explains that the cover takes care of any expenses arising from injuries and the medical bills thereof. This policy, however, comes with minimum requirements in terms of the value of liability insurance that drivers can claim. In particular, for any driver wishing to take this cover, it is better to take one that is above the minimum coverage requirement in your respective state (Boylan and Mark 2009). This is because this provides added protection in case one is found on the wrong for an accident since in that case the insured is to cater for any expenses exceeding the policy limit A policy holder can also take Medical Payments Coverage. Under this arrangement, the premiums paid by the policy holder cover for any medical expense incurred in the event anyone is injured the insured’s car. Essentially, this policy disregards the driver who causes the accident. This means even the insured was on the wrong, the insurance company still indemnifies the insured (Boylan and Mark 2009). According to Weiss Insurance Company, it is clear that the cover is inclusive of the insured’s family members. In this regard, a family member involved in an accident as either driver or pedestrian will have their medical expenses billed on the insurance company. This coverage’s are unique in every state, with some states covering the medical payments under the (PIP) personal injury protection. This is also referred to as no-fault insurance. Besides, potential policy may also consider taking uninsured/ underinsured motorist protection. Although this motorist has been widely advocated to be mandatory in most states, this has, however, not been the case. Important to note is that many states have relatively low requirements in the minimum requirements. Consequently, the liability insurance is invariably insufficient to cater for additional arising expenses (Boylan and Mark 2009). This means that for an individual responsible for a particular damage, you won’t receive any payment without coverage. Conversely, if your coverage indicates to be less than the value of the damage caused, you are bound to receive less than the amount required to cover the entire expense for the damage. In these two situations, uninsured and underinsured motorist policies help with the expenses. It is usually much cheaper for an insured individual to adopt this insurance policy, particularly considering the protection it offers. In addition to these, policy holders can also take up collision coverage that caters for repairs relating to the car. However, for worn out cars or cars whose values prove to have really depreciated considerably, eligibility for this insurance cover is limited. Similarly, for new or relatively expensive cars, collision coverage is the best cover to adopt if an insurer is seeking to be indemnified. This is because insurance companies may opt to repay the policy holders’ car if it was totally damaged. Also considered is the case whereby we have a lien holder. In such an event, this coverage is mandatory. References Boylan, Ed, Scott Werfel, and Mark Swercheck.  Automobile Insurance Made Simple. USA: Universal Publishers, 2009. Print.

Prom Nights from Hell Chapter Eleven Free Essays

Eighteen minutes later, deputy Sergeant Caleb Reynolds stood outside the door of the director’s office, watching them through a crack. It had taken him slightly longer than expected to get everything in place, but he felt good, confident, about how it was all going to play out. Especially now seeing the two girls in the Bee’s Roller Derby outfits, tight little skirts and tops, even had the wigs and masks on. We will write a custom essay sample on Prom Nights from Hell Chapter Eleven or any similar topic only for you Order Now They were identical except one of them was in blue, the other in white. Like little dolls, yeah, he liked to think of them that way. His little dolls. Expensive dolls. The blue doll saying, â€Å"Are you sure the fact that you want to kiss him isn’t getting in the way of your judgment, Miranda?† And the white doll saying, â€Å"Who says I want to kiss him? You’re the Kissing Bandit.† â€Å"Who says I want to kiss him?† the blue doll mimicked. â€Å"Please. You should really learn to have some fun. Live in the mo.† â€Å"Maybe I will as soon as I get rid of you, Sibby.† The blue doll stuck out her tongue, almost making him laugh. They were cute together, these two. Blue doll said, â€Å"I’m serious. How do you know we can trust him?† â€Å"He has his own agenda,† the white doll explained, â€Å"and it works with ours.† Then he really did have to stifle a laugh. She had no idea how correct she was. About that first part. And how wrong about the second. He pushed the door open and saw them both turn to him with you-are-my-hero expressions in their eyes. â€Å"Are you ready, Miss Cumean?† Blue doll nodded. His little white doll saying now, â€Å"Take good care of her. You know how important she is.† â€Å"I will. I’ll get her settled and come back for the second part of the operation. Don’t open the door for anyone but me.† â€Å"Right.† He was back less than a minute later. â€Å"Was everything okay? Is Sibby safe?† â€Å"It went perfectly. My men were exactly in position. It could not have gone smoother.† â€Å"Okay, so how long do we wait before I run out?† He walked toward her, backing her against the wall. He said, â€Å"There’s been a change of plans.† â€Å"What, you’ve added a part where you kiss me? Before the part where I pretend to be Sibby and lead the guards into the SWAT-team trap?† He liked the way she smiled when she said it. He reached up to caress her cheek and said, â€Å"Not exactly, Miranda.† His hands slid from her face to her neck. â€Å"What are you tal-† Before she could finish, she was pressed against the wall, hanging a foot above the ground, his hands around her throat. He tightened them slightly as he said, â€Å"It’s just you and me now. I know all about you. Who you are. What you can do.† â€Å"Really?† she choked out. â€Å"Yes, really. Princess!† He saw her eyes get wide and felt her swallow hard. â€Å"I knew that would get your attention.† â€Å"I don’t know what you’re talking about.† â€Å"I know about the bounty on your head. Miranda Kiss wanted, alive or dead. My original plan had been to leave you alive for a while, bring you in after a few weeks, but unfortunately you just had to interfere. Should have minded your own business instead of mine, Princess. Now I can’t run the risk of your getting in the way.† â€Å"You mean in the way of what you’re doing with Sibby? So you were the one who wanted the money. You betrayed those others and made them think you were part of their cause, just like you betrayed us.† â€Å"Such a smart girl.† â€Å"You kill me, kidnap her, and collect money? Is that it?† â€Å"Yep. Just like Monopoly, Princess. Pass go, collect two hundred dollars. Only in this case it’s more like fifty million. For the girl.† â€Å"Wow.† She looked genuinely impressed. â€Å"And how much do you get for me?† â€Å"Dead? Five million. You’re worth more alive; apparently some people think you’re some teen Wonder Woman, have superpowers. But I can’t take the chance.† â€Å"You already said that,† she rasped. â€Å"What, are you bored, Miranda?† He tightened his grip a little. â€Å"Sorry this wasn’t more of a storybook ending,† he said, smiling at her, holding her eyes with his own as he choked her. He could tell she was struggling to breathe now. â€Å"If you’re going to kill me, can’t you just get on with it? This is kind of uncomfortable.† â€Å"What, my hands? Or the feeling that you’re a failure-â€Å" â€Å"I’m not a failure.† † – again.† She spit in his face. â€Å"Still got some fire. I really admire that about you. I think you and I could have gotten along nicely. Unfortunately, there just isn’t time.† She gave one last fight, clawing at him with all her remaining strength. It was inspiring how hard she worked. Finally her little fists fell hopelessly to her sides. He leaned in close to her face. â€Å"Any last words?† â€Å"Three: Listerine breath strips. You really need them.† He laughed, then tightened the hands around her neck until they overlapped. â€Å"Good-bye.† For a second, his eyes burned into hers. Then there was a sharp crack and something heavy came down on his head from behind. He staggered forward, his hands letting go of the girl as he fell to the ground unconscious. He never knew what hit him, the blue doll thought, still gripping the clock she’d used to knock him out. Or who. How to cite Prom Nights from Hell Chapter Eleven, Essay examples

Innovation and Development for American E-commerce- myassignmenthelp

Question: Discuss about theInnovation and Development for American E-commerce. Answer: Introduction Amazon is known across the world as a largest cloud computing and the biggest American e-commerce company. 1994. The Company formerly acknowledged for selling books through its website and afterward commenced the digital version of books. The brand in built of customer service, inventory, and shipping empire. This business strategy offer Amazon with everything from merchandise to the janitorial supplies. Amazon has a vast range of products that includes digital content like movies, music, and apps. Their customers include government agencies and universities. Amazon has become the chief player in consumer electronics by selling devices like Fire tablets and TV boxes. Recently the brand has added Alexa AI assistant service, making news at the CES 2017. Amazon is constant Hollywood player, winning home two awards at the 2017 Golden Globes (Amazon, 2017). This states the strategy of Bezos's is to develop a long-term customer loyalty over short-term profits. Amazon has introduced an ever -lasting development into novel businesses opportunities. Innovation Amazon is astonishingly gaining market year after year. Amazon has an obsession with efficiency. They are known for adding innovation by delivering products in just two hours through Prime Now service. Amazon is the first e-commerce Company to set up its own fleet of drones through Amazon Prime Air. This is a future fleet of self-directed aerial vehicles. These drones will deliver products below 5 pounds. Moreover, Amazon opened its bookstore in Seattle. There are plans to open and more in 2017. These stores are unlike the traditional bookstores. The Amazon stores comprise of machines that permit shoppers to read user reviews (Nyln and Holmstrm, 2015). Amazon Prime is known across the world as a paid subscription service offered by Amazon.com. The service offer customers to access free one-day delivery, streaming video/music on monthly or yearly fee. Prime has more than 80 million paying users as on April 2017. This innovation in the company is measure as a catalyst to inhibit growth (Johnson, 2017). Following are the interesting points about the innovative services provided by Amazon Prime: Prime Membership is a channel to add market share consolidation and revenue growth. Retail stocks increased crosswise the board in anticipation of Prime Day just to solidify its success. The Estimated Prime Day earning is over $1 billion They Will persist the retailer's for Q4 holiday sales Relevant theories Environmental and organizational conditions Amazon is known across the world for innovative services and added market advantage. In a very short period the company has gained a significant market. It is operating in every part of the world. Change is an inevitable part in an organization (Johnston and Marshall, 2016). To understand the innovation, it is important to understand the changes taking place in the Macro environmental factors. These factors are important to understand the level of changes taking place in the environment. The first part is to manage the changes in order to manage the changes. It is important to focus on the technology changes that will help in meeting the decided results (Nyln and Holmstrm, 2015). Political The business is highly affected by the political situation of the countries it is operating. This includes any kind of political instability, law and order. Amazon Prime is accessible to most of the countries. However there are certain restrictions depending upon the political atmosphere. There are certain norms that regulate the innovation. Amazon believes on adding innovative aspect to an organization (Rutkauskas and Ra?inskaja, 2013). Economic factor The economic factor is related with the purchasing power of the people. An economy with a good purchasing power will make purchases. In case of Economy Downturn, the economy is reluctant to make expense. The purchasing power of People in UAE is increasing developing the market. Prime is a better option for the brand to develop itself in order to grow properly. This strategy is important from the point of view of innovative changes. These changes are important for the economy (Cetindamar, Phaal and Probert, 2016). Social factors The society and culture is important for the economy. This affects the growth of the company. The innovative practice is developing growth in the country hence increasing the overall capacity. An increase in the online services and Netflix environment has created an opportunity to derive the effectiveness (Dodgson, et al 2013). Technological With the advancement in technology and innovation, there is an increasing opportunity in the field of Amazon prime services. These services are important for managing the growth. The entire world is changing at a fast pace. This is creating opportunities for the technological aspect. These changes in technology are important for the company in order to maintain its market position. The new technology changes in the prime services are an important aspect in dealing with the innovative invasion. In such a situation, this is important to overcome the issue related to the innovative invasion. Amazon prime is able to organize changing in a better way (Christiansen, Gasparin and Varnes, 2013). This will help in meeting the changes that are taking place in the modern environment. The theories are in support of the organizational development and gaining productive results. Amazon is surprisingly gaining market year after year. Amazon has an obsession with efficiency. They are known for addin g innovation by delivering products in just two hours through Prime Now service. By adding new innovative measures, it is possible to gain competitive advantage over the other companies (Lai, et al 2014). Success of the plan Amazon prime and Amazon TV are the huge market success. Even after having so much of competition, the company is performing incredibly well in the sector. Prime has more than 80 million paying users as on April 2017. This shows the dedication of the team on managing the organizational goals. This really reflects the efficiency of the brand in whole. In case of failure There were very few chances regarding the failure of the Amazon prime services. In case of failure, it is evident to add a better innovation in order to gain market growth. Transition initiatives can be taken in future by involving the interest of the customers across the globe. Amazon then needs to derive its strategy from unique local experiences. This will help the company in working consistently. Organizational processes The organizational process is important for Amazon prime to introduce changes at different places. These processes are important for managing changes in an effective way. The changes are implemented in order to manage the business activities, organizing like planning is applied to the process (Euchner, and Ganguly, 2014). At Amazon the purpose is to bring the activities in a regular framework by gaining competitive advantage. The end result is important to harmonize task in order to manage the changes (Camisn and Villar-Lpez, 2014). Review plans and objectives. The existing Objectives are in relation with the specific activities that are important to achieve goals. In order to plan in a better way, the activities needed to reach those goals. The Managers has to examine the growth and plans in order to continue focus on new goals are changes (Weng 2014). Determine the work activities necessary to accomplish objectives There is a balance in between the planning process. This task appear to be overwhelming to some managers, Managers analyse the tasks required to be accomplished in order to reach organizational goals (Chatterji, 2016). Classify and group the necessary work activities into manageable units The manager can practice the group activities based on four models of departmentalization: functional, geographical, product, and customer. Assign activities and delegate authority The Managers has to work with specific individuals. These activities have helped in managing the task in the most appropriate way. They have achieved authority to carry out the assigned tasks. While managing the task in an appropriate way it is the duty of the leader to handle the changes that are taking place in the organization. It is one of the important facility that is been provided by the organization in order to cope up with the consequences. The purpose of this strategy is to guarantee growth by managing the efforts in an effective way (Carland et al 2015). All this is helping in managing the organizational task on a long run. It is important for a business organization to update the process in the changing business environment by overcoming the guaranteed growth in the innovation. The process of innovation and knowledge is important to guarantee better opportunities. This help in managing the organizational goals in order to get effective results. The purpose of the technolo gy is to meet the guaranteed growth by accomplishing the result while managing the task in a proper way (Chell, et al 2016). Design a hierarchy of relationships For an organization, it is important to manage design of the team in an appropriate way by organizing the strength and the weakness. These teams are important for carrying out the organizational goals in an appropriate way. The purpose of a team is to manage the task by coordinating the relationships of the organization as a whole. Being a multinational organization, Amazon has a responsibility of managing the organization (Davidsson, 2015). This is important to organize the effectiveness of the team in order to organize a consistent growth. The purpose of a team management is to establish long-term relationship in an organization. It is through a pro-active approach to manage the solution in an effective way. The hierarchy system helps in allocating the resources in the best possible way (Drucker, 2014). The cognitive process The process of decision making is important for an organization in dealing with the decision making process. Amazon has a clear approach to achieve sustainable results by establishing goals on the basis of learning and development. The business process is based on consistent innovation and technology services. This will allow the business in managing the business activities in support of the organizational growth. The service offer customers to access free one-day delivery, streaming video/music on monthly or yearly fee. Prime has more than 80 million paying users as on April 2017. This shows the dedication of the team on managing the organizational goals (Glaeser, et al 2015). The process thereby focuses on a consistent approach while managing the business activities in a well- effective way. The learning process is important for Amazon in meeting the results by applying the designated process. The team learning is important for introducing a change in the team and to take appropria te measures. The approach is important for managing the changes in order to gain appropriate results. This is important for an organization in meeting the result in order to gain appropriate result. Overall the process of learning is important for an organization in meeting the targets. This is important for an organization in gaining appropriate result over the period of time (Kirzner, 2015). The team processes The team process is important for gaining organizational goals. In order to manage a team, it is important to develop a team and to implement appropriate result. These results are important for matching up with the expectation of the people. The organizational change is important for an organization in order to deal with the changes. This is important to facilitate the growth in order to manage the organization. The purpose of an organization is to sustain changes and to avoid resistance. This resistance can only be avoided by the process of team management and development. The entire process of team management and development is significant for the growth of the innovative team. These teams are important for achieving a consistent growth. The purpose of an organization is to manage the changes in the best possible way. The team process help in incorporating changes in the best possible way (Patil, 2013). These changes are important for the organization in meeting the objective. This is manageable according to the upcoming process and changes in the business environment. The purpose of the organization is to incorporate changes by looking onto the ongoing changes and development. The culture and leadership The organizational culture at Amazon is non-hierarchical. People are free to introduce a change into the team. This is only possible if the organization understand the importance of team management and development. These changes are important for gaining effective result. The purpose of the organization is to manage the changes in an effective way. Amazon prime is able to organize changing in a better way. This will help in meeting the changes that are taking place in the modern environment. The theories are in support of the organizational development and gaining productive results. While implementing a change, it is important to develop an effective plan in order to manage consistent growth and development. The organizational culture is important for managing the changes in order to gain competency. The culture plays an important role in gaining competency in order to gain better result. This is necessary to be focused on managing the tasks in the best possible way. Amazon has an o bsession with efficiency. They are known for adding innovation by delivering products in just two hours through Prime Now service. The direction of the organizational leader at Am111azon acts as a supportive measure. This is important for gaining market competency in order to gain better results (Rajak, et al 2015). Implementation processes The important part in an innovation exercise is to implement changes. These changes are important for the organizational growth and development. It is hence important to incorporate changes and innovation in an appropriate way to gain market competencies. The changes can only be managed if the organization is aware about the market changes these changes are important to develop innovative practice. These practices are important for managing the organizational goals (Read, et al 2016). The outcomes of the innovation like organizational performance, further innovation, knowledge gained, etc. Is important parameter to consider a consistent outcome? Once an innovation is done it is important to manage the business function by organizing an appropriate business activates. These business activities are important for organizing the result by matching up with the organizational expectation (Schap et al 2014). This is important for the company in order to gain market competencies. The process of implementation is important to gain market competency. In the innovative business atmosphere, it is necessary to incorporate changes in a definite way. The changes are very important for an organization in order to gain competencies. This is important to manage the business activities to function in a proper way. These changes are important for an organization in order to meet the changes in an appropriate way. The factors associated with the organizational growth and development is important for managing business function (Storey, 2016). Evaluation of the factors influencing the development of the innovation (from the initial problem/opportunity through to implementation The factors are important for managing the changes in order to gain market knowledge. The innovation is important to gain competency. Innovation is an important aspect in managing competitive business environment. These changes are important for gaining competitive advantage to Amazon. The nature of innovation and development is the primary motive of an organization. The main purpose here is to present a holistic approach in order to manage innovation. An organization is affected by the ability to innovate changes taking place at different level. For an organization, these are the important parameter to derive competitive growth. This present before significant relationships recognized between the factors to present a clear approach. The organization is to gain market competencies in order to manage the activities in order to gain competitive results. This is important from the point of view of organizational growth antidevelopment t in order to gain competencies. From this, it is im portant to develop innovation management as a dynamic process in order to manage the organization. Instead of focusing on a singular factor the purpose is to diversify the knowledge in order to gain competitive advantage. These factors are important to understand the level of changes taking place in the environment. The first part is to manage the changes in order to manage the changes. Evaluation of the outcomes of the innovation Amazon Prime is a market success and gained market advantage in order to manage the innovation. The process of managing changes and development is important to gain consistent growth. The Amazon prime services have gained market strength in order to gain market advantage. These factors are important for managing the organizational growth. The services are well-accepted worldwide. After the revolution of technology and development at Amazon, it is well-accepted fact that the organization is making tremendous changes in the market. They are instituting effective changes helping in managing effective growth. There are plans to incorporate changes in coming time. These changes are important for an organization in order to organize effective growth and development. On the other hand it is important to manage the innovative changes in order to manage the market changes. These changes are important for organizing changes in an appropriate way. The Amazon stores include machines that permit shoppers to read online user reviews for each item. These are important factor in managing the business activities in an effective way (Nyln and Holmstrm, 2015). Conclusion To conclude, this is an important exercise to manage the innovation and development in the organization. It is an important task necessary to manage the innovation in a better way. Amazon is an innovative organization making changes as per there growing market needs. These changes are important to gain effective growth. In a very short period the company has gained a significant market. It is operating in every part of the world. Change is an inevitable part in an organization. The market changes are important from the point of view of innovative exercise in order to gain market advantage. References Amazon, 2017. Online. Available at: https://www.fastcompany.com/company/amazon Accessed on: 3 October 2017 Camisn, C. and Villar-Lpez, A., 2014. Organizational innovation as an enabler of technological innovation capabilities and firm performance.Journal of business research,67(1), pp.2891-2902. Carland Jr, J. W., Carland, J. A. C., Carland III, J. W. T. (2015). Self-actualization: The zenith of entrepreneurship.Journal of Small Business Strategy,6(1), 53-66. Cetindamar, D., Phaal, R. and Probert, D., 2016.Technology management: activities and tools. Palgrave Macmillan. Chatterji, M. ed., 2016.Technology transfer in the developing countries. Springer. Chell, E., Spence, L. J., Perrini, F., Harris, J. D. (2016). Social entrepreneurship and business ethics: does social equal ethical?.Journal of Business Ethics,133(4), 619-625. Christiansen, J.K., Gasparin, M. and Varnes, C.J., 2013. Improving design with open innovation: A flexible management technology.Research-Technology Management,56(2), pp.36-44. Davidsson, P. (2015). Entrepreneurial opportunities and the entrepreneurship nexus: A re-conceptualization.Journal of Business Venturing,30(5), 674-695. Dodgson, M., Gann, D.M. and Phillips, N. eds., 2013.The Oxford handbook of innovation management. OUP Oxford. Drucker, P. (2014).Innovation and entrepreneurship. Routledge. Euchner, J. and Ganguly, A., 2014. Business model innovation in practice.Research-Technology Management,57(6), pp.33-39. Glaeser, E. L., Kerr, S. P., Kerr, W. R. (2015). Entrepreneurship and urban growth: An empirical assessment with historical mines.Review of Economics and Statistics,97(2), 498-520. Johnson, G., 2017.Exploring strategy: text and cases. Pearson. Johnston, M.W. and Marshall, G.W., 2016.Sales force management: Leadership, innovation, technology. Routledge. Kirzner, I. M. (2015).Competition and entrepreneurship. University of Chicago press. Lai, Y.L., Hsu, M.S., Lin, F.J., Chen, Y.M. and Lin, Y.H., 2014. 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The Finger Of Blame In MacBeth Essays - Characters In Macbeth

The Finger of Blame in MacBeth Macbeth is a very exciting story containing all kinds of plots and murders. The characters that are killing and are planning murders are all very deceiving and treacherous. Two of the most dangerous criminals in this play are Lady Macbeth and her husband. Together they commit the most dreadful murder by killing the King; Duncan. This is why it is difficult to determine which one of these two is more guilty, because they each do their own part in committing the crime. Lady Macbeth would prepare the plan and then encourage Macbeth to go through with it. Macbeth did the actual murdering, he was also the first person who thought about killing Duncan. Furthermore he did some killing on his own. Lady Macbeth did not have any involvement in these cases. Based on these facts, Macbeth would be found more guilty than Lady Macbeth. The very first murder in this story was committed on Duncan. This crime was planned by both Macbeth and Lady Macbeth. The actual murder was done by Macbeth, making h im more guilty of the crime. Lady Macbeth just talked about committing the crime, but she never actually went through with it nor would she ever, and that is all that counts. Talking about committing the incident is very different from actually doing it. Lady Macbeth did a little more than just talk about it though. She also urged Macbeth into doing it and that is what makes her part of this crime, but she is not as guilty as Macbeth. He really didn't have to listen to what his wife said. Macbeth had a mind of his own and he could make his own decision. The other murders that Macbeth was involved in were not committed by him, but were ordered by him. The people who did the killing had no choice, they had to do it, because they worked for Macbeth. Macbeth knew this and was a bit more guilty in these murders then lady Macbeth was when she urged him. The idea of killing Duncan first came from Macbeth. Macbeth listened to the witches prophecies that said he would become King. Macbeth di d not want to wait any longer and he thought the only way to become King was to kill the present King; Duncan. Macbeth later told Lady Macbeth about this and she just wanted to help him and do whatever she could for him, so that he would be happy and be King. She was also excited about becoming a Queen so she pushed Macbeth forward and did not let him back down from doing what he said he'd do. Macbeth had a good chance of becoming King if Duncan was out of the picture, so Lady Macbeth helped stage a plan so that Macbeth could kill him without being caught. Lady Macbeth wanted to do this for herself as well but she was mostly doing this for Macbeth because she loved him so much. Macbeth is a regular murderer throughout the play and is involved in a lot more murders then Lady Macbeth is. She was only involved in the murder of the King while Macbeth was killing people throughout the whole story. He killed lots of men fighting for the King, and later on he killed the King. After killing the King he ordered some of his men to murder Banquo and Fleance, Fleance got away though. Later on through the story when Macduff went to join Malcolm, Macbeth had Macduff's family killed. Macbeth was a man that murdered far more people then his wife did. So he was a more guilty person then she was. Through the story Macbeth got obsessed with killing others and he wanted to kill more, while Lady Macbeth became so self conscience that she went crazy and killed herself. Throughout the course of the story it is tough to decide who is a more guilty person, but if you look at it through the eye's of today's law you will see that Macbeth is more guilty of murder. This is because he had killed a lot people before he killed the King, and when he did kill the King by

Gentlemans Agreement essays

Gentlemans Agreement essays Philip Greenwood is a magazine reporter that is offered a job in New York to publish a series on anti-Semitism. Greenwood is having a hard time finding an angle approaching the Hebrew religion. After several nights of no leads he decides to write his good friend from childhood and wants to ask, what is it like to be Jewish? Realizing just before he begins to type, there is no way of fully understanding what it feels like to be a minority unless he pretends to be Jewish himself. In order for him to make this project work few people know the truth about the new man that has arrived in New York City. Philip is a tall slender man with dark features such as his hair and eyes. He is able to pass as Jewish. What Greenwood doesnt realize is that it will effect his entire life style and the ones he loves. The project is under way, and he notices that with in one day word has spread throughout the entire magazine company that a new Jewish man has been assign an article to publish. Problem after problem start to occur after Philips little boy comes home from school confused on what religion he is. Greenwood explains to Tommy that in order to fully understand what it feels like to be Jewish he is acting as though he of the same religion. Philip has little problems along the way, until Dave is back from being over seas. Dave is the long time friend who faces the cruel world every day by being Jewish. Dave and Philip and another reporter go out on the town for a couple of drinks to talk about the old times. While Dave is sitting down in a chair, a rude man bumps in to him and asks his name. After hearing his last name the man was ready to fight. Philip had to step in between the two. He soon realized that anti-Semitism is no joke. Greenwoods project had been going along for about one month and he and his soon to be wife were having difficult times as well. P ...

Saving the Publishing Industry Using Technology Case Study

Saving the Publishing Industry Using Technology - Case Study Example The case study also entails what the book publishers and newspaper industries have done, to ensure that there is no phasing out of their products due to internet use. Many opinions are in this case study which leads to change in their business models (Hendricks, 2011). The measures that the industries have taken to gain from the internet and e-books are in consideration, in the case, and the role that technology plays in ensuring that the newspaper and book publishing industries do not fail due to the internet are in the case study. Considering product design and sales following the value chain model, there is consideration of the internet which helps in the reduction of over 60 percent of new staff and another 60 percent of the newspaper on sale. There has been a decline in readership; this also applies to the number of advertisements. This is because there are alternative online sources including Yahoo, social blogs, and Google. This is according to the research by Martin & Tian (2 010). Considering the research and development aspect, the internet through online newspapers and books is a disruptive technology that has led to the destruction of traditional models of business that involve physical distribution and physical products. The book publishing industries and newspaper are changing their business models by sharing revenue with the partners of the internet including Yahoo and Google, so as to ensure that they generate some revenue as a result of their content is on the internet. There is fee charge for newspaper content delivered to news reading devices including e-readers, Smartphone, tablets, and IPads enabling online newspapers to read at any place according to Brown (2002). The book and newspaper industries are charging fees for news and opinion which are premium. Placing advertisements on online newspaper has been on the rage so as to increase the revenue from advertising.

Critical Article Review -Race, Gender, Labor in 1960's Memphis Essay

Critical Article Review -Race, Gender, Labor in 1960's Memphis - Essay Example The article’s strength lies in its exploration of black men’s emasculation and their eventual â€Å"feminization† brought about by the labor and working conditions in the 1960s (Green 467). From the oral interviews, the author was able to elicit insightful responses about the gender, racial, and labor issues encountered by black men. By placing these responses side by side with a short narration of black slavery and the civil rights movement, the author clearly shows the underlying motivations of the black men who coined the slogan. The conclusion about black women appropriating the slogan for themselves, meanwhile, extends the article’s significance in the areas of feminism and ethnicity. Not only does the article examine black men’s opinions about the slogan, but the author also includes the perspective of women which, in turn, sheds light on the values women hold in feminist studies, and their sense of identity in ethnicity studies. For women, the slogan ‘I Am a Man’ means â€Å"justice† (Green 467), an assertion of courage (Green 474), or â€Å"freedom† (Green 475). Again, the author clearly establishes the different meanings attached by black women to the slogan through the oral interviews. The article’s lack of structure, however, weakens the conclusion and disorients the reader. There are no headings that organize the article’s main thesis and guide the reader to the introduction, literature review, findings, etc. The article flows continuously as a 25-page document without any breaks in between. In one paragraph, for instance, the author talks about the civil rights movement and then jumps into an interview of a black female in the next paragraph.

Fired for Creativity Essay Example | Topics and Well Written Essays - 750 words

Fired for Creativity - Essay Example In order to complete a case analysis on his story, initially, before answering six essay questions, this paper will first provide a summary of Lasseter’s experience from a management perspective. According to the Power and Politics in the Fall and Rise of John Lasseter, the creative man’s employment background, the early attraction to animation began in his freshman year of high school and only intensified when he began his formal education in the field. Upon being hired at Disney, Lasseter worked emphatically to progress the animation department to the ways of the future by introducing the idea of films based solely off computer-generated imaging. While his intentions were honorable, Lasseter acknowledges that his drive may have created instances where he seemed like a loose cannon. After a particular meeting where Lasseter was allowed to create a test film to demonstrate the viability of using both hand drawn animation and computer generated imaging, he was immediatel y fired by a supervisor who did not care for him. This instance is where the case analysis can determine a clear problem with management style. The problem with what happened to Lasseter is that his employment termination was obviously personal in nature. It seems ridiculous that an employee of a creative company could be terminated for simply being creative. Furthermore, Lasseter had no outstanding work infractions. For whatever personal reason that this studio head did not care for Lasseter, the employee was fired unjustly. Personal feelings must be worked out in a professional manner versus being dealt with professionally which can often go the wrong way, as we see in this example. Fortunately for Lasseter, this unjust retribution did not last as the young animator was hired by Steve Jobs and helped him in the creation and success of Disney’s Pixar and the outstanding films the company produced. The analysis of this scenario demonstrates that while younger employees can fi nd themselves at a disadvantage when it comes to dealing with their more tenured and older counterparts, there is always hope in the fact that someone else will see them and value their creativity. Questions 1-6 1. What forms of interpersonal power are evident in the case? Within the case of Lasseter and the studio head who did not care for him as a person, the types of interpersonal power being used are those of status and age. As the older, more experienced employee, the studio head knew he had the upper hand in the situation as he had the more advanced job title to effectively be able to have Lasseter fired without due cause. 2. In what ways do the two faces of power appear in this case? The two faces of power in this case are first, the studio head who chose to have Lasseter unjustly fired. By simply using his power to make this happen, the studio head used the power of his position and office politics to have the young artist fired. The second face of power in this case is that of Steve Jobs himself. The actions of Jobs allow him to act as the hero in this story as he is able to see the value in this employee and hire him back on for Pixar. 3. Does the firing of John Lasseter from Disney Studios and the events leading up to his firing demonstrate the ethical use of power? Explain

Pre Industrial England 1450-1750

Pre Industrial England 1450-1750 Pre-industrial England was a period that laid the foundation for the industrial revolution. Its too vast with numerous changes that may seem to contradict itself if confined to a single definition. In the early beginnings of the period, the ratio of population to land was low, with small rural communities heavily engaged in agriculture. Markets were imperfect, along with simple/sluggish technology mostly because, the pre-industrial man was unaccustomed to innovation or simply did not see the need for cost reducing innovations. The method of production was mostly labor intensive with little capital equipment if any at all. The description thus far is fitting for the period 1450-1650. During this period population growth fluctuated widely, mostly because of famines and diseases. It is worthy to note that the family was the foundation of the home economy and in aggregation the essence of the pre-industrialized economy. The family structure was the source of knowledge, wealth and in many cases legitimacy (particularly in the case of women). During this age, England was a pyramid of status. Ownership of land was the materialization of status and the quickest way to political leverage. This set in motion the incentive for development: the desire to acquire more land through the plouging back of profits into the purchase of land. It was during this time that the concept of RENT was developed. Though the industrial revolution started in Britain, during the period 1450-1650 England was behind its continental counterparts in almost every economic respect. Though population growth fluctuated, it had an upward trend; unfortunately the primitive economy was unable to absorb this surplus labor. Consequently, pre-industrial Britain was plagued with unemployment and underemployment. As if the latter was not bad enough, high mortality rates forced a young population to work and an overwhelming climate of beggars and vagabonds emerged. One interesting way the economy sought to absorb the excess labor was through the immigrations of this surplus to cities e.g. London. Europe had long been competing among itself for new markets and raw materials. This led to the beginning of colonialization and the discovery of new lands. Britain had long been and persisted to be an exporter of mostly raw materials. Before boats and new trading routes were invented and discovered, trading was problematic and capital accumulation was down right impossible. The medium of exchange was poorly defined and barter proved to be complex because of the double coincidence of wants. In the mid 15th century, there was an evident shift in the export of raw materials to manufactured goods, mostly the export of cloth. (refer to Fig 1 p 50) Very quickly cloth export accounted for 2/3 of all exports, most of which were destined for colonial territories and Low Countries. In light of this positive change, England was still largely a primary product producer, as such; they had a high import dependency on continental Europe. Through immigration, England was able to import new skills and techniques and in some cases capital. While England began to harness the power of this intake, there was a discovery of gold in South America. This made capital accumulation a little less difficult and further fueled trade. Though industrial jobs were seasonal because productive activities were predominantly dependant on the seasonality of crops, glimpses of urbanization could be seen. Artisans and craftsmen were the first manufacturers who often worked with just an apprentice; their capital formation was small, nevertheless, growing. The location of industries were dependent on the labor supply and occupations of all nature started to emerge and change continually as taste, fads and fashion change. In the book, the economy of England 1450-1750 by D.C. Coleman: England was described as having habit of à ¢Ã¢â€š ¬Ã‚ ¦borrowing and improving, rather than inventingà ¢Ã¢â€š ¬Ã‚ ¦ Though homegrown inventions occurred, this habit was embedded in the English national trait. In light of this copy cat approach of the English, from the 17th to 18th century, English patents had increased drastically. Patents in this case are used as a proxy to represent the quantity of inventions/innovations. See fig. 2 p 154. In brief, English industry in the century from 1650 to 1750 can exhibit a variety of innovations, some of a radical nature in that they are represented injections of capital equipment which had the effect of raising productivity. Some involved a new use of power-driven machinery or opened up new possibilities therein, for example, in silk-throwing or cotton-spinning, some saw a replacement of one important input in the production process by another, for example, coal for charcoal, steam and atmospheric pressure for horse- or man power. The quote above taken from the economy of England 1450-1750 by D.C. Coleman, adequately sums up the importance and impact of the innovations taken place in England at the time. Pre-industrial England (Analysis) Why was the pre-industrial age the way it was? Or, how did it transform into the industrial revolution? I will seek to explain or find some bearings to answer these hard questions. My analysis will be confined to a few fundamental elements of capitalism: property rights, capital accumulation, profit motive, institutions, and level of technology and government intervention. It is known that low labor productivity, poor education, high fertility and mortality rates along with the dominance of physical over human capital plagued the pre-industrial period. The reverse is true when compared to modern societies, which is characterized by low fertility rates and extreme emphasize on human capital. What accounted for the spurts in population growth that forced the surplus labor to immigrate to the cities? With little education and sluggish technology there was roughly an average level of human capital. Earnings and benefit from investing in human capital were both low, and the typical agricultural laborer earned their maximum income at age 20.. Thus, parents would choose quantity as opposed to quality in child bearing; this sheds some light on the reasons population boom. High mortality rates also forced parents to reproduce at a high rate and began to prepare an army of labor that flourished during the industrial revolution. The number of patents issued (used as a proxy for capital accumulation) signals the rate of capital accumulation and developments in technology. Of course, these changes pale in comparison to modern standards but it laid a foundation that was essential to the industrial revolution. Reference was made in the overview regarding Britains culture of borrowing and improving, this also sought to cement the foundation of technological changes during this period. The pre-industrial mans desire for status and political accomplishment along with the desire to be favored by the crown, propelled the pre-industrial age. Granted, at a slow rate. This was mostly done through the conquering of new lands and meager changes (compared to modern standards) to productive activities. Imperfect markets were able to a limited extent however, to fuel the industrial mans profit motives. Nevertheless, this remains one of the few underlying elements of capitalism that never wavered or seems to fade. The pre-industrial age was preserved through the family structure, and the family structure was preserved through the ownership of lands. All the essential elements of capitalism were in existence and growing in every respect during this primitive age. True, it has evolved since, but that is not a demerit, rather, the reason why its able to survive all these years. At the heart of this period, the crown/state/government played a most vital role in industrial planning. Colonies were set up, trade agreements were made, and many accomplishments were made in the name of the crown. The crown was very much involved in Britains development. The states role and power had changed remarkably over the years, but we include it as an essential element of capitalism to illustrate the crucial role of government in jump starting an economy. Industrialization (750-1830) The industrial revolution was basically a fundamental change in the structure of Britains economy. It was the reallocation of resources away from agriculture. Britain being the first nation to become industrialized in the mid 18th century experienced rapid growth. These high growth rates would involve changes in every aspect of the economy. Britain rich iron, coal and reliable source of waterpower were essential to the industrial revolution. Colonies around the world supplied Britain with raw materials e.g. cotton and wheat and served as a market place for manufactured cloth. These colonies helped to stimulate the textile and iron industries, the wealth then generated by these two industries is what drove the industrial revolution. The steam engine was the greatest innovation of the industrial revolution because it became an instrument for applying basic innovations in many industries and transport. In the 1800s industries such as cotton spinning and iron was dependent on the steam engine. Landowning and farming wealth flowed to investment for improving land and transport while commercial wealth flowed to industry. Institutions created incentives and encourage innovation for entrepreneurs. The acceleration of industrial development was facilitated by the emergence of institutions such as financial systems, legal systems, and social institutions. Since the economy was growing at a steady pace, financial systems were needed to support this profound change: the established of the banking system in the 1690s. The banking system began to mobilize savings more widely after the 1750s. The bank of England, the London private bank and the country bankers made up the banking system. The problem with capital accumulation in the 18th century was one of establishing a tube by which capital could flow from the groups who were making the savings to those who really needed the credit. During the industrial revolution laws were enforced which required all land to be fenced at the expense of the owners. This caused many families to borrow from banks. Women and children made up 75% of the workers, this was because they were easily manipulated into accepting low wages which kept the cost of production low and profits high. Children were preferred since they had smaller hands; which was often needed to fit into parts of the machines. The laissez faire approach of the government allowed capitalism to flourish. There was little or no government regulations imposed upon factory policies. In the industrial ages the states role was basically to institutionalize social and economic forces and to provide security at home and abroad in which market forces would operate. Since they worked 18hrs per day they spent no real time together as a family, hence the industrial revolution contributed to the break down of the family unit. The living conditions were horrible because the cities became over crowded. Families lived in factory houses. These houses had no more than three to four rooms, more than one family then had to occupy a room. Other families who couldnt afford the rent of the factory houses lived in slums with little sanitation, as a result mortality rates were high (infant mortality rates were 50%) The legal system endorsed property rights and extended the concept of property to such assets as shares, bills of exchange, bank notes and patents. There was a pyramid concerned with land use. At the top there were the landowners, they comprised of temporal lords, gentlemen and freeholders (better sort and lesser). The lesser freeholders were the ones who owned and tilled their own land. They formed the middle class, the employing class who were the backbone of the agricultural economy. The others rented their land to the second group who where the land cultivators. These land cultivators formed a mixed group; which included small freeholders, owner-cultivators, the family-worked farm, the small holders and squatters. The third group, which was the base of the pyramid were the farm laborers; the proletariats. In the 18th century government began to intervene by implementing factory act, which aimed at securing the welfare of children. Industrial revolution Analysis This analysis will be based on the fundamental elements of capitalism: property rights, capital accumulation, profit motive, institutions, and level of technology and government intervention. It will answer why and how these elements changed/ developed during the industrial ages. Unlike the pre-industrial age capital accumulation wasnt as difficult. The emergence of foreign trade and the banking system made capital accumulation easier. Now the question is how and why these systems did emerge? Capital was accumulated through property ownership but also with the expansion of trade, that is: as trade increased, more money was demanded which was later provided for by gold and silver. The foundation of the bank of England in 1694 was part of a deal made between the government, (desperately short of finance in wartime) and the leading merchants and financers. Capital goods industries began to emerge mainly because of worldwide industrialization and the increased accumulation of capital through investment. This development led to mass production, and was responsible for the increase in British iron output during the 1830-1840 and continued to increase until the 1880s which also led to an increase in the employment of coalminers. The expansion of these industries changed most of the social problems that were present in the initial phase of industrialization: it gave unskilled workers better paid jobs, and improved working conditions which increased dramatically in the 1850s. The profit motive has been the driving force towards industrial capitalism. It encourages firms to operate more efficiently thus, promoting competition among rival firms. It served as the catalyst for production, distribution and consumption. Why did the level of technology change? Because of changing demand and the enlarged size of the markets promoted the development of new methods of production, often through innovation and adaptation of already existing technology. POST INDUSTRIALISATION The post industrialized period, is defined in this paper as that span of time in which Britains economy began to make the transition between what can be termed as Industrial Capitalism to Financial Capitalism. This simply means a decline in Britains manufacturing industry and growth of the financial sector. Why the manufacturing industry declined? To address this we need to consider many factors: the first important factor to is seen as the change in the power of the people that is the labor laws reforms and the electoral laws reforms. During the early and mid years of the industrialized period there was little power for the working class, they had no right to vote unless they owned property. They had no voice in the workplace, no way of expressing their displeasure and swift and harsh actions were taken against those who refused to obey the law.. Coming to the end of the industrial period and into the post, there were a number of reforms and acts introduced to change this fundamental problem within Britain. Firstly in 1871 trade unions were made legal, and they were allowed to strike. However it was not until 1875 that the legal act, Conspiracy and Protection of Property Act, was implemented to allow workers to peacefully strike at their place of work. But after terms of revolts in the working populace, into being came the Labor government party, and during their term (1906) they brought into being the Trade Disputes Act, which declared that unions could not be sued for damages done during a strike. In this respect, the power of the working class grew tremendously as compared to the earlier years of industrialization. But these Labor laws were not the only important reforms being made during this period to address the power of the people; in fact they went synonymously with the reforms being made to the electoral system. In the mid 18th century, The Great Reform Act (1832) gave vote to only male householders who held a certain amount of property. In time it was evident that this act was generally met with an outcry from the working population who paid taxes. This displeasure of the populace led to a Second Reform Act (1867) which allowed many of the working class men living in towns to cast a vote. However this system was still at fault because voting was done in the open and men were forced to stoop to pressures of their employers and landowners, that is- to vote in their interest. So upon recognition by the aforementioned, the labor government party introduce The Secret Ballot which allowed men to vote in seclusion, away from the pressures of their employers and land owners. But the second reform act was still deemed inadequate because it still failed to capture a decent proportion of the population, so came The Third Reform Act, in 1884. This new act now gave voting rights to adult male householders in Britain- which encompasses those living in the country areas. But with the exclusion of women, the system was still insufficient. After many womens rights movement there was a new act passed called the People Act of 1918 which gave voting rights to all men over the age of 21 and all women over the age of 30. This single act propelled the size of the electorate from 7.7 million to 21.8 million! This was not the end however, soon after the Equal Franchise Act of 1928 gave voting rights to all women over the age of 21 on the same terms the men had. And then finally, a new Representation of the People Act gave voting rights to everyone over the age of eighteen. The changes in the electoral and labor laws caused the emergence of a new phenomenon in Britain. The wants and demands of the people were now stronger and more politicians were more eager to meet them. Given the new found power of the populace, workers were now entitled to a larger share of the Gross Domestic Product (in future will be addressed as GDP). The general standard of living was now a principle that could no longer be ignored; the happiness of the entire Britains populace was now the centre focus of all politicians and no longer only the sole happiness of the entrepreneurs. As such some manufacturers found it unprofitable to keep on running when they can no longer access cheap labor, and governments found it necessary to implement many social safety nets to keep its populace happy. As stated before, addressing why the manufacturing industry declined we need to look at many factors, so far the populaces power has been addressed. The next important issue that needs attention is that of world trade. The British economy at the beginning of the industrialized period was well noted for some of the greatest inventions in the world. They were at one point in time even addressed as the workshop of the world. This advantage Britain had over the world market stemmed from their great inventions, namely; the stream engine, the railway train, the coke burning blast furnace, the power loom, the spinning jenny and the water frame. In time, the increasing globalization that took place in the latter years of the industrialized period caused her to lose this advantage. Aero planes and motorcars were made by the French, German and American inventors, thus, the comparative advantage Britain held significantly declined in the later years of its industrialized period. In the early years of industrialization Britain had rich coal and iron ore near the surface, but by the mid 19th century all the cheaply accumulated coal and iron were gone. Although there were deeper reserves, the advantage of the resource endowment significantly decreased. That being said, the British population growth began to significantly slow down in the late 19th century at that critical time when the American population began to grow rapidly. The power of British rivals increased rapidly, via their population growth and innovations as such Britains power in the world market was proportionately reduced and their manufacturing industries were left behind. . Britain was deemed as lucky to procure investors within its economy to help propel it during its industrial ages. Heading steep into the 20th century it was evident that an agglomeration of capital was invested in foreign industries, since the British investors saw it as more profitable to establish business overseas. It was a good investment for the British entrepreneurs but it also helped develop industries abroad, those industries to rival that of Britains. The invention of the railway and the telegraph system in the mid 19th century encouraged banks to expand and establish branches distances away from the main offices. Many people lost money when they invested into small banks, so government regulations were introduced to make it easier for larger banking groups to be formed. There was security in any particularly large bank. In mid 19th century The Bank Charter Act was introduced in order to reassure customers that their dollar invested in the bank was equivalent to gold sovereigns. This particular regulation had an enormous effect on bankers everywhere, the bigger banks became even more secure than the smaller ones, and as such mergers became ultimately inevitable. The Midland bank was a small bank founded in 1836 by Charles Greach. But by the late 20th century there were 200 branches of the Midland Bank stationed in London alone. It was clear; mergers were now a common thing within Britains financial industry. Britains financial sector continued to grow until it became a landmark within it one of the largest and richest cities in the world London. Britain had developed other major financial institutions such as the London Stock Exchange and The Commodity Market. This city had become known as the center of the worlds finances. Britains current account deficit at the time would have led to a crisis but the foreign investments Britain had secured were more than enough to cancel out the trade deficit. It is common knowledge that Britain had fought two world wars and surprisingly enough these foreign investments helped finance the wars. Britain had run up massive debt during the First World War, particularly with the United States of America, she had claimed to borrow an estimate of  £959 million. This was not the end however; even with the great lost in wealth (approximately a quarter of Britains wealth was lost) there was an introduction of liberal economic policies, which pushed Britains economy further down with slow growth rates and high unemployment. The national debt had increased 11 times what it used to be. Britain also had a streak of bad debts as she could not have expected repayment from loans given to Russia because of the communist takeover, nor could she expect the loans she lent to France because of the war damages France had incurred. To manage her empire Britain decided to implement her Ten Year Rule, it stated that she did not expect to fight another war for at least ten years. As such there were major defense budget cuts to make up for the debt owed. This impact as would be expected further restricted Britains foreign policies. So the impact of the First World War significantly influenced and restricted Britains empire. Continuing into the early 20th century, Britain felt the wraith of the American economy In the 1930s Britain experienced unemployment of 22.8%, but then a decrease to 13.9% in 1936 to 10% in 1938. But also, Traditional industries such as textiles and coal mining were severely affected by the depression. So it was evident that there was even further decline in the manufacturing sector during this period. There was also deflation in the economy at the 1930s as prices for food and rent fell by approximately 15%. Into the Second World War Britain plummeted, and it emerged in greater financial upheaval. It lost about an average of 12% of its productive capacity. By the 1940s British exports were in a decline by 35% as compared to 1935. Britain had almost exhausted its gold and dollar reserves on ammunitions, raw materials and some industrial equipment. Britain had even borrowed a further $31.4 billion dollars from the United States, as it was estimated near bankruptcy. So after the Second World War, Britain had lost support from the United States lend lease program, which was said to be the life support of Britain at that time. Now with its huge lost in wealth the two world wars began to take its toll on Britain. So after supporting Britain in the wars, countries demanded their independence, and decolonization started with Indias independence in 1947. Britain was also losing its old markets as commonwealth agreements were made to only do regional trade with local and regional entities. It is here Britain took a strong structural change from the manufacturing industry towards the services industry, in this regard many industrialized parts of Britain was left in a steady state. There were then packages with the intent of nationalization, as government tried to take hold of the economy. Devaluation of the pound was made, Britains economy still experienced low growth rates, and the new Labor government was unable to solve the problem. In came the famous Margaret Thatcher who implemented many economic reforms, leading to deregulation and privatization of major industries. Competition policy was the forefront of her ideology which replaced that of industrial policy. This resulted in high unemployment rates, but subsequently led to significant increases in growth rates. The British economy continued to experience rapid growth straight into the 1990s, with the exception for the recession experienced in the early quarters of the 1990s. Advances in technology continued to help the British economy and the conservatives kept rule until 1997, when they were taken over by Tony Blairs labor party. Blair introduced policies to reduce unemployment, gave power to the Bank of England to set interest rates and then introduced the minimum wage in Britain. But the Blair government decided to stick with the spending plans of the conservatives, and the economy kept on moving. Heading into the 21st century, the labor party increased taxes and borrowing, utilizing the money for public services. The growth rates in this era were kept constant, but the pound value fluctuated. The Britain kingdom was fairly well off, during the 21st century until it experienced the 2008 great recession, which was deemed as the worst recession since the Second World War. POST INDUSTRIALIZATION ANALYSIS As stated in the beginning, this period is defined as that in which Britains economy made a transition from a manufacturing based system to a financial based system. The aim of our paper is to understand how capitalism changed (transitioned) from the previous periods into this one. We have noted that this change in Britains economy was not the result of one particular factor; it was the agglomeration of many important fragments. It had begun with the simultaneous changes in the populace, capital accumulation and world trade. But it was more so propelled by the impacts of the two world wars and the many changes that stemmed from them. As compared to the previous two periods it was realized that the people of Britain had no say in any decisions being made for the country unless they had some significant amount of capital. Due to many constitutional reforms by the state this defining phenomenon of the populace had changed. The force behind these reforms came from pressures behind new founded labor institutions such as the trade unions. The need of these institutions, however, had originally stemmed from the pressure the industrialized period placed on its laborers. The world trade had laid upon Britain an enchantment of the profit motive. But guided by policy systems and development of financial institutions the profit motive inhibited growth in Britains domestic investment. This restriction led to a gradual decrease in Britains comparative advantage in the industrial world market. But although the profit motive had caused Britain to eventually export more than they import, it had changed Britains national accounting figures. So the profit motive had transformed Britains economy as it became more dependent on increases in invisible trade and not so much on the production and exports of goods. Capital accumulation and the profit motive however were not the sole signatories to the reforms in Britain, its necessary to make mention of the impact of technology on the system. At the beginning of the industrial period Britain had the advantage because they had the best technology in the world. But this did not stay as such, since given time, the major inventions in the world were not British. Some argue this was because technology booms are random and usually are only directly affected by significant investments in research and development. Britain had fought two world wars and it had emerged victorious but not without its economical burdens. After the first world war Britain had to restrict is international polices as it incurred major national debt. But after the Second World War, Britain was hanging on to America to keep functioning. It had lost nations due to demand for decolonization, and it lost world markets due to new trade restrictions from Caribbean countries. The promotion of deregulation, privatization, and competition polices let to a recovery of the economy. Monetary policies were transformed- allowing the Bank of England to set interest rates. These changes promoted massive growth of the British economy and the recovery of the system. It is also during this time frame that the government made decisions that define post industrialization today. The government set their famous safety nets in this period. They set: minimum wages, increase taxes and increase their public services. These safety nets are what vastly distinguish this period from previous ones, in the two previous ages there was no concern for the well being of the British populace as compared to the post industrial age. Britains Development via Industrialization A Critical Analysis As outlined in the heart of this paper Britain had traveled through three periods each leading successfully to the next. The paper seeks to illustrate how essential the fundamental elements of capitalism are to a nations development. It identifies the uniqueness of capitalism and its resilience in light of contradictory forces. There had been fierce debate over the roles of government and the effectiveness/fairness of protectionist policies in national development. Contrary to modern literature and advocates for free trade, Britains advantage in the industrial period (protection of infant industries) was maintained by strong protectionist measures and governments hand at each door step of the economy, (from the 17th to 18th centuries). The philosophy/ideology of mercantilism reigned for at least a hundred years: the belief that the source of a nations wealth is through the barring of imports whilst boosting exports. This gave Britains industries an advantage of a hundred years. Sectors were able to develop, change and learn from their mistakes. Most importantly, they were able to become efficient and specialist within their fie

Genetically Modified Foods Cause Autism Essay -- GMOs Essays

Question: Through the use of genetically modified foods, are humans becoming more prone to abnormalities? Introduction I have chosen to do my Life Science research project on genetically modified food as it is a topic that interests me. I have formulated a research question which is â€Å"Through the use of genetically modified foods, are humans becoming more prone to abnormalities?† Genetically engineered organisms (GMO) are becoming so advanced and a large variety of food that we eat has been genetically modified, such as maize, cotton, potatoes, wheat, sugarcane, strawberry, and soya. (Appel, 2008) With the increased advancement of GMO, many people are unaware of the complications that can occur. In my project I will be researching whether or not GMO are an addition to the cause of cancer and autism, but first in order for us to understand the effects of genetically modified organisms, we need to gain an in depth knowledge of the basis of genetics. DNA and Chromosomes Deoxyribonucleic acid (DNA) is a â€Å"hereditary material in humans and many other organisms† (Education, 2014). DNA is found in the nucleus of the cell. DNA forms an important part of the chromosome. DNA is a molecule that contains all the genetic information to make up an organism. DNA is a double helix structure made up of deoxyribose sugar, a phosphate and a nitrogenous base, there are four nitrogenous bases, Adenine, Thymine, Guanine and cytosine. Base pairing is specific. DNA carries genetic information in each cell, DNA can also replicate itself, so that the genetic code is passed on to each daughter cell that is formed during mitosis. â€Å"A chromosome is a thread-like structure of nucleic acids and proteins that are formed in living cells† (Anon., 2014).... ...3 Feburary 2014]. University of Nebraska , 2001. Ag Biosafety. [Online] Available at: http://agbiosafety.unl.edu/education/summary.htm [Accessed 16 March 2014]. University of Nebraska, 2005. Ag Biosafety. [Online] Available at: http://agbiosafety.unl.edu/basic_genetics.shtml [Accessed 03 Feburary 2014]. Unknown, 2011. Siyabonga Africa. [Online] Available at: http://www.krugerpark.co.za/krugerpark-times-2-6-genetically-modified-foods-19358.html [Accessed 01 May 2014]. Walia, A., 2013. Collective Evolution. [Online] Available at: http://www.collective-evolution.com/2013/05/10/new-study-links-monsantos-roundup-to-autism-parkinsons-and-alzheimers/ [Accessed 20 February 2014]. Wang, P., 2013. Autism Speaks. [Online] Available at: http://www.autismspeaks.org/blog/2013/10/11/are-children-born-autism-or-does-it-develop-later [Accessed 05 May 2014].

Biochemistry perspective Essay

Diabetes is an ailment which is caused due to high amount of glucose (sugar) in the blood. The main reason for high glucose levels in blood is due to the inability of body to utilize it properly. Glucose comes from the digestion of sugar and foods rich in carbohydrates that enable the liver to create glucose. The high concentration level of glucose in blood is termed as Hyperglycemia. In 1910, Sir Edward Albert Sharpey-Schafer suggested people with diabetes were deficient in a single chemical that was normally produced by the pancreas. He proposed calling this substance insulin. The term is derived from the Latin insula, meaning island, in reference to the islets of Langerhans in the pancreas that produce insulin. (Patlak, 2002) Insulin: An Introduction Insulin is a polypeptide containing 51 amino acids arranged in two chains. The chain A contains 21 amino acids and chain B contains 30 residues. These two chains are cross linked by two sulphur bridges by cysteine residues. Insulin is formed by proteolytic cleavage of its 84 amino acid prescursor Proinsulin. Insulin has a molecular weight of 5808 Da. It has the molecular formula C257H383N65O77S6. Insulin structure varies slightly between species. Its carbohydrate metabolism regulatory function strength in humans also varies. Porcine which is pig insulin is close to humans. The image above is computer-generated image of insulin hexamers. The zinc ions holding it together and the histidine residues are involved in zinc binding. Insulin Action A pharmacological action of insulin includes carbohydrate metabolism, protein metabolism, lipid metabolism and other actions. Insulin increases the use of sugar in the tissue and stimulates transportation of glucose into the cells. Insulin also stimulates protein synthesis and growth. It increases synthesis of messenger RNA and decreases gluconeogenesis. A gluconeogenesis is a formation of glucose from glycogen. It also increases amino acid uptake in the muscle. In adipose tissues, insulin increases fatty acid synthesis, glycerol phosphate synthesis and triglyceride deposition. Other action of insulin includes prevention of ketone boy formation and increases potassium uptake. After the release of insulin from the pancreatic beta cell into the interstitial compartment, it enters the circulation after crossing endothelial barrier. Insulin action effect at the cellular level is achieved by activating and suppressing the activity of enzyme. It can also be achieved by changing the rate of synthesis of enzymes at the level of transcription and translation. Insulin stimulate glucose uptake into fat cells by glucose transporters. Glucose transporters are small vesicles which contain specific protein macromolecules. Insulin increases the rate of fusion of these vesicles with the plasma membrane, and activates the transporters to transfer glucose across the plasma membrane into the cell. Insulin synthesize hoxokinase, an enzyme which phosporylates glucose as soon as it enters the cell. Insulin is an anabolic hormone. It encourages the storage of fats and the synthesis of proteins. Each receptor of insulin contain a pair of alpha subunits, which are located on the outer surface of the membrane, and a pair of beta subunits which crosses the membrane and stick out at both the outer and inner surfaces. Both alpha and beta subunits are held together by disulphide (S-S) bonds to form an aggregate. In humans, the insulin receptor gene is located on chromosome 19. Insulin binds to the receptor at a specific site on the alpha subunit. This causes increased phosphorylation of the receptor by ATP, mostly tyrosine residues of the intracellular portion of the beta subunit. Increased phophorylation of these tyrosine residues activates the beta subunit to function as a kinase enzyme. Some intracellular effects of insulin that occur after insulin-receptor binding may be mediate through nucleotide regulatory proteins (G proteins) a family of proteins associated with the inner surface of the plasma membrane. Cyclic AMP also has some intracellular effects of insulin. The major function of insulin is to counter the concerted action of a number of hyperglycemia-generating hormones and to maintain low blood glucose levels. Because there are numerous hyperglycemic hormones, untreated disorders associated with insulin generally lead to severe hyperglycemia and shortened life span. In addition to its role in regulating glucose metabolism, insulin stimulates lipogenesis, diminishes lipolysis, and increases amino acid transport into cells. Insulin also modulates transcription, altering the cell content of numerous mRNAs. It stimulates growth, DNA synthesis, and cell replication, effects that it holds in common with the insulin-like growth factors (IGFs) and relaxin. Specific protease activity cleaves the center third of the molecule, which dissociates as C peptide, leaving the amino terminal B peptide disulfide bonded to the carboxy terminal A peptide. Insulin secretion from beta cells is principally regulated by plasma glucose levels. Increased uptake of glucose by pancreatic b-cells leads to a concomitant increase in metabolism. The increase in metabolism leads to an elevation in the ATP/ADP ratio. This in turn leads to an inhibition of an ATP-sensitive K+ channel. The net result is a depolarization of the cell leading to Ca2+ influx and insulin secretion. In fact, the role of K+ channels in insulin secretion presents a viable therapeutic target for treating hyperglycemia due to insulin insufficiency. Insulin, secreted by the beta-cells of the pancreas, is directly infused via the portal vein to the liver, where it exerts profound metabolic effects. These effects are the response of the activation of the insulin receptor which belongs to the class of cell surface receptors that exhibit intrinsic tyrosine kinase activity as shown in the figure. Insulin produces its action through specific insulin receptors which consist of two subunits ? and ?. Insulin receptor complex then initiates a chain of biochemical reaction involving cAMP, protein phosphorylase, protein kinase, phosphatase and lipase. A diabetic condition result when receptor of insulin is desensitization. Therefore, Insulin is used medically in diabetes mellitus. Patients with type 1 diabetes mellitus depend on insulin (commonly injected subcutaneously) for their survival because they make no hormone. Patients with type 2 diabetes mellitus have either low insulin production or insulin resistance or both. Therefore, they require insulin administration when other medications become inadequate in controlling blood glucose levels. Actions of insulin-insulin receptor interactions at the level of IRS1 and activation of the kinase cascade leading to altered activities of glycogen phosphorylase and glycogen synthase. The insulin receptor is a heterotetramer of 2 extra cellular alpha-subunits disulfide bonded to 2 transmembrane beta-subunits. With respect to hepatic glucose homeostasis, the effects of insulin receptor activation are specific phosphorylation events that lead to an increase in the storage of glucose with a concomitant decrease in hepatic glucose release to the circulation. Only those responses at the level of glycogen synthase and glycogen phosphorylase are represented. This image shows Insulin-insulin receptor actions on glycogen homeostasis showing the role of protein targeting glycogen, PTG in complex formations involving many of the enzymes and substrates together. Also diagrammed is response of insulin at the level of glucose transport into cells via GLUT4 translocation to the plasma membrane. GS/GP kinase = glycogen synthase: glycogen phosphorylase kinase. PPI = protein phosphatase inhibitor. Arrows denote either direction of flow or positive effects, T lines represent inhibitory effects. In most nonhepatic tissues, insulin increases glucose uptake by increasing the number of plasma membrane glucose transporters: GLUTs. Glucose transporters are in a continuous state of turnover. Increases in the plasma membrane content of transporters stem from an increase in the rate of recruitment of new transporters into the plasma membrane, deriving from a special pool of preformed transporters localized in the cytoplasm. GLUT1 is present in most tissues, GLUT2 is found in liver and pancreatic b-cells, GLUT3 is in the brain and GLUT4 is found in heart, adipose tissue and skeletal muscle. In liver glucose uptake is dramatically increased because of increased activity of the enzymes glucokinase, phosphofructokinase-1 (PFK-1), and pyruvate kinase (PK), the key regulatory enzymes of glycolysis. Lack of Insulin Usually the inefficiency and lack of insulin are bracketed together, as both situations result in diabetes. There are two types of diabetes, diabetes insipidus and diabetes melitus, which is by far, the most common. Diabetes mellitus in turn has two types: Type 1, also known as insulin dependent diabetes mellitus, IDDM Type 1 is characterized by decreased productions of insulin so must be treated with insulin. It is most often found in children and adolescents. Type 2, also known as non-insulin dependent diabetes melitus, NIDDM Type 2 is caused by either decreased insulin production or abnormal cell sensitivity to the insulin that is present. It may be treated with diet alone, with oral hypoglycemic agents, or with insulin. It is more commonly diagnosed in adults. (Perspective Press, 240-43) Insulin does not cure diabetes. It is merely a treatment for the diabetes. Over time, many complications can occur in diabetic patients taking insulin. Some of these are coronary heart diseases, peripheral vascular diabetes, eye disorders, renal failure, and limb amputations. Because of reduced circulation and nerve damage, diabetic patients are essentially prone to developing foot ulcers, a major cause of amputations. They are able to feel foot infections, which allow it to grow and cause permanent damage. Proper foot care is essential and includes avoiding injuries oral restricting circulations, cleaning wounds, controlling infections, relieving weight from the ulcer area, and improving circulation. A new genetically engineered drug, becaplermin, promotes the healing process in diabetic foot ulcer. Lack of insulin or ineffectiveness of it may trigger some response from the body. The predominant tissue responding to signals that indicates fluctuating blood glucose levels is the liver. One of the most important functions of the liver is to produce glucose for circulation. Both elevated and reduced levels of blood glucose trigger hormonal responses to initiate pathways designed to restore glucose homeostasis. Low blood glucose triggers release of glucagon from pancreatic Alpha-cells. High blood glucose triggers release of insulin from pancreatic Beta-cells. In elderly people pancreas either fails or does not secrete right amount of insulin. In this patient insulin per injection becomes drug of choice when oral antidiabetics have failed. Insulin was also used to induce shocks in schizophrenics. Insulin secretion is controlled by concentrations circulating glucose, amino acids, and fatty acids, various hormones and neuron-transmitter agents. In the fasting state, when glucose concentrations are low, insulin secretion is minimal. As glucose concentrations rise after the utilizing carbohydrates meal the raised glucose concentration stimulates insulin secretion. Insulin resistance develops over time. Therefore, doses have to be increased. This occurs because of the development of insulin antibodies in the blood. This also can be somewhat corrected by changing the type of insulin injection and by giving cortiscosteroids which are immunity suppressant drugs. Yet, it also produces negative effect by increasing blood sugar and this is why they are not used. Types of Insulin There are many types of insulin and many salt forms of it. It can be derived synthetically of from different animal sources such as beef and pork. There is now genetically engineered human insulin available. Different insulin differs in the onset of action and the duration of action. Some are mixed together to achieve a desired effect such as a quick onset but a longer duration of action. The most common mixtures is regular insulin with NPH insulin (70units NPH and 30 units regular insulin per milliliter) The different categories of insulin’s are: 1. Short-acting insulin types: regular insulin (crystalline zinc insulin), semilente insulin (prompt insulin zinc suspension), insulin lipsor; 2. Intermediate – acting insulin types: NPH (isophane insulin suspension) and linte insulin (insulin zinc suspension); 3. Long-acting insulin types: PZI (protamine zinc insulin suspension) and ultralente insulin (extended insulin zinc suspension). Administration Insulin is injection instead of giving orally because it is destroyed in the gastrointestinal tract. Also, the molecule is too large to be absorbed by the intestinal membrane. Therefore, injection of soluble crystalline insulin is given by subcutaneous injection which is quickly absorbed. Peak effects of insulin are achieved quickly and also excreted quickly within a few hours. However some insulin such as simelente is absorbed slowly. The peak is reached slowly and is sustained. This type of insulin excretion is also very slow and sometimes partly destroyed by insulinase enzyme in the liver. Controlling glucose level with insulin injections is a complex task since: a) Glucose concentrations fluctuate based on food ingestion. b) Cell sensitivity to insulin changes. Exercise increases sensitivity while stress, pregnancy, and some drug decrease insulin sensitivity. As a result some diabetic patients take multiple injections for a short-acting insulin preparation to produce peaks in insulin concentrations and a long acting formulation to establish a baseline concentration. Variable rate infusion pumps are also used. Patients who use insulin need to be instructed on the rotation method of taking their medication. Insulin is absorbed more rapidly with administration in the arm or thigh, especially with exercise. The abdomen is used for more consistent absorption. Glucose levels should be checked as per physician orders. All insulin must be checked for expiration date and clarity of the solution. Insulin should not be given if it appears cloudy. Vials should not be shaken but rotated in between the hands to mix contents. If regular insulin is to be mixed with NPH or lente insulin, the regular insulin should be drawn into the syringe first. Unopened vials should be stored in the refrigerator, and freezing should be avoided. The vial in use can be stored at room temperature. Vials should not be put in glove compartments, suitcase, or trunks. Humulin is a new type of insulin and is often the patient’s preference because it can be taken orally. It is imperative that the physician be called if any adverse reactions to the medications are observed. (Jahangir Moini, P 150-154) Undesirable Effects Insulin The main undesirable effect of insulin is hypoglycemia. This is common, and can cause brain damage. Intensive insulin therapy results in a threefold increase in severe hypoglycemia. The treatment of hypoglycemic is to take a sweet drink or snack, or, if the patient is unconscious, to give intravenous glucose (50% w/v solution) or intramuscular glucagon. Rebound hypergly (Somogyi effect) can follow excessive insulin administration. This results from the release of the insulin-opposing or counter-regulatory hormones in response to insulin-induced hypoglycemia. This can cause hypercemia before breakfast following an unrecognized hypoglycemic attack during sleep in the early hours of the morning. It is essential to recognize this possibility to avoid the mistake of increasing (rather than reducing) the dose of insulin in this situation. Allergy to insulin is unusual but may take the form of local or systemic reactions. Severe insulin resistance as a consequence of antibody formation is rare. A high tire of circulating anti-insulin antibodies is more likely to occur with bovine than with porcine insulin. Note, however, that virtually all patients treated with animal insulin have antibodies against the hormone, albeit usually flow. Human insulin is less immunogenic than animal insulin but may still evoke an antibody response, since the source of the hormone is not the only determinant of immunogenicity; insulin undergo physical changes before and after injection which can increase their potential for provoking an immune response. (HP Rang et al, 200-270) References 1. Patlak M. 2002. â€Å"New weapons to combat an ancient disease: treating diabetes†. Available on http://www. fasebj. org/cgi/content/full/16/14/1853e 2. Perspective Press. 2003. â€Å"The Pharmacy Technician† 1st edition: Morton Publishers. P 240- 243. 3. Jahangir Moini. 2005. â€Å"Comprehensive Exam Review for the Pharmacy Technician†: Thomson Delmar. P 150-154 4. H. P. Rang, M. Maureen Dale, James M. Ritter, Philip Moore. 2001. â€Å"Pharmacology†: Churchill Livingstone. P 200-270